Formulation and in-vitro Evaluation of Oro-dispersible tablets of Indomethacin

Introduction: Oro-dispersible tablets are rapidly dissolved in saliva without the need for water and beneficial renal impaired, bedridden psychiatric patients. Objective: The study aimed to formulate oro-dispersible of indomethacin with reduced adverse effects, better patient compliance, faster action, convenience Methods: were prepared using three different super disintegrants; crospovidone, croscarmellose sodium starch glycolate concentrations (2.5%, 5.2%, 7.7%) by direct compression method. evaluated pre post-compression parameters including bulk density, tapped compressibility index, angle repose, Hausner's ratio, hardness, friability, wetting time, vitro disintegration drug release. Results: percentage released 5 minutes all formulations Indomethacin was found be 74.36% 80.16% 10 96.18% 100%. All showed time range 19-78 seconds. 7.7% crospovidone (F6) shows (19 seconds) as compared sodium. in-vitro dissolution studies that batch containing releases 100% after which fast Conclusions: profile other superdisintegrants.